Relationship: Triglycerides (high) and EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid primarily found in marine sources such as fish oil, has robust scientific validation for its use in lowering high triglyceride levels. Multiple large-scale, randomized controlled trials and meta-analyses have demonstrated that EPA supplementation significantly reduces serum triglyceride concentrations, particularly in individuals with hypertriglyceridemia. EPA is thought to exert its triglyceride-lowering effects by reducing hepatic very-low-density lipoprotein (VLDL) synthesis and secretion, enhancing beta-oxidation of fatty acids, and inhibiting lipogenesis in the liver. Prescription formulations of EPA (such as icosapent ethyl) are approved by regulatory agencies like the FDA specifically for the treatment of severe hypertriglyceridemia. Clinical guidelines from organizations such as the American Heart Association and the Endocrine Society recommend EPA-containing omega-3 fatty acids as an adjunct to diet in patients with elevated triglycerides, especially when lifestyle modifications alone are insufficient. Importantly, EPA may have a more favorable safety and efficacy profile compared to mixed EPA/DHA formulations, particularly in terms of not raising LDL cholesterol. The REDUCE-IT trial (2019), which used high-purity EPA, demonstrated not only significant reductions in triglyceride levels but also a decrease in major cardiovascular events among high-risk patients. Thus, the use of EPA for lowering triglycerides is well-supported by high-quality scientific evidence and is integrated into current clinical practice.

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Other ingredients used for Triglycerides (high)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-hydroxyisoleucine
Adzuki bean
Akkermansia muciniphila
algal oil
Algal protein
Algalin
Alliin
Almond fruit
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
anthocyanins
apple
arabinoxylan
argan nut oil
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
ashwagandha
astaxanthin
astragaloside
avocado
banaba
beet
berberine
bergamot
beta-glucan
black currant
black garlic
black ginger
black tea
blueberry
bottle gourd
Brassica
Brazil nut
broccoli
brutieridin
Buckwheat
Buglossoides arvensis
calamari oil
Calanus finmarchicus
California chia
camelina oil
capsiate
cardarine
carnosic acid
cashew
catechins
chia seed
Chinese fleeceflower
Chitin-Glucan Complex
chitosan
chlorogenic acid
chokeberry
choline
cocoa
cod liver oil
Coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
coriander
corosolic acid
crocetin
cruciferous
Crypthecodinium
cyanidin
cynarin
daidzein
daidzin
danshen
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
diosgenin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Echium
Ecklonia
eicosapentaenoic acid
Eicosatetraenoic acid
emblicanin
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
eriocitrin
fish
fish protein
Flammulina velutipes
flavanols
flavanones
flaxseed
fo-ti
fruit and vegetable blend (proprietary)
fucosterol
fucoxanthin
genistein
genistin
Ginsenosides
glucomannan
Glucoraphanin
goji berry
grape
grapefruit
green tea
guar gum
guggul
Guggulsterones
Gypenoside
hawthorn
hesperetin
hibiscus
horse gram
hydroxycinnamic acid
hydroxytyrosol
inulin
Irvingia gabonensis
isoflavones
jiaogulan
Jicama
Kaempferide
Kaempferol
kale
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kidney beans
kiwi
knotweed
Konjac
krill oil
kuding tea
kudzu
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l-carnitine
L-taurine
lecithin
Legume protein
Lentil
lignans
lingzhi
linoleic acid (LA)
linseed oil
lupin
lycopene
macadamia
magnesium
mangiferin
maqui berry
Marine fat
Maslinic acid
Matcha
Mate
Millet
Monacolin
Monounsaturated fat
Mortierella alpina
Mulberry
Myricetin
Nannochloropsis
Naringenin
Naringin
Niacin (vitamin B3)
Nobiletin
oat
oleanolic acid
oleic acid
Oleuropein
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oolong tea
Osthole
oyster mushroom
palmitoleic acid
pantethine
perilla
Phaeophyceae
phospholipids
Phytoestrogens
Piceid
pine bark
Pinolenic acid
Pistachio
Plankton
plant sterols
Pleurotus eryngii
Plukenetia volubilis
polychitosamine
Polydatin
polymethoxylated flavones
polyunsaturated fat
pomegranate
pomelo
pu-er tea
Puerarin
punicalagins
purple tea
quercetin
quinoa
rapeseed oil
red yeast
red yeast rice
resveratrol
Rooibos
Rosa roxburghii
S-allylcysteine
Sacha Inchi
safflower oil
Salacia
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Salidroside
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Salvianolic acid
Schisandrins
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sesame
Sesamin
Sesamolin
Shilajit
Silybin
silymarin
Sitosterol
Soy
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soybean
spirulina
Stearidonic acid
sterols
Stilbenoid
strawberry
sunflower
Tagatose
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Tanshinone
Taurine
Taxifolin
Tejocote
Tetradecylthioacetic acid
Theabrownin
Theaflavin
Thylakoid
tocotrienols
Trans-pterostilbene
Trimethylglycine (TMG)
ubiquinol
Ursolic Acid
vegetable and fruit blend (proprietary)
vegetable oil
Vegetable Protein
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vitamin C
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Zinc
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Products containing EPA (eicosapentaenoic acid)

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Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: EPA (eicosapentaenoic acid)For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Triglycerides (high)