Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid commonly found in citrus fruits and is the aglycone of hesperidin. Its potential lipid-lowering effects, including on triglycerides, have been investigated in both animal and human studies, though the evidence is still emerging and not robust. Some preclinical studies, primarily in rodent models, have demonstrated that hesperetin supplementation can reduce serum triglyceride levels, likely through mechanisms that involve modulation of lipid metabolism, improvement of insulin sensitivity, and anti-inflammatory effects. For example, hesperetin has been shown to activate peroxisome proliferator-activated receptors (PPARs), which play a crucial role in lipid homeostasis.

In limited human research, a few small clinical trials have evaluated hesperetin or hesperidin supplementation (often as part of a citrus extract) and observed modest reductions in triglyceride levels. However, results are mixed, with some trials showing no significant changes. The doses and formulations used also vary widely, making it difficult to draw clear conclusions. Systematic reviews and meta-analyses of flavonoids as a group suggest possible benefits for lipid profiles, but evidence specific to hesperetin for triglyceride reduction remains preliminary.

Overall, while there is some scientific rationale and early research suggesting hesperetin may help support healthy triglyceride levels, the quality and quantity of clinical evidence are limited. Larger, well-designed human trials are needed to confirm efficacy and establish optimal dosing.

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