Evidence supporting the use of: Hesperitin
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hesperitin, a flavonoid primarily found in citrus fruits, has garnered scientific interest for its potential lipid-lowering effects, including the reduction of high triglyceride levels. Several preclinical studies and a number of small-scale human trials suggest that hesperitin and its glycoside precursor, hesperidin, can beneficially modulate lipid metabolism. The hypothesized mechanisms include inhibition of hepatic lipid synthesis, enhancement of fatty acid oxidation, and improvement of insulin sensitivity, which collectively can contribute to lower serum triglyceride concentrations.

Clinical evidence, though still limited, indicates that supplementation with hesperidin or hesperitin can lead to modest reductions in triglyceride levels in individuals with metabolic syndrome, hyperlipidemia, or related conditions. For example, a meta-analysis of randomized controlled trials published in 2019 found that citrus flavonoids, including hesperidin, significantly reduced triglyceride levels, though the effect sizes were generally small and the studies varied in quality and duration. Animal studies have provided more robust evidence, consistently demonstrating triglyceride-lowering effects, but translation to humans requires further large-scale, high-quality trials.

In summary, the current body of scientific literature provides moderate support for the use of hesperitin in managing high triglycerides, justifying a mid-range evidence rating. However, hesperitin should not be considered a replacement for established lipid-lowering therapies at this stage, but rather as a potential adjunct, pending further research.

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Products containing Hesperitin

We currently have no products on Vitabase that contain this ingredient.