Evidence supporting the use of: Isoquercetin
For the health condition: Triglycerides (high)
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Isoquercetin is a flavonoid compound found in various fruits and vegetables, and it is a glycoside form of quercetin. There is some scientific evidence suggesting that isoquercetin and related flavonoids may have beneficial effects on lipid metabolism, including triglycerides. Several in vitro and animal studies have demonstrated that isoquercetin can reduce serum triglyceride levels, likely through mechanisms involving antioxidant activity, inhibition of lipid absorption, and modulation of enzymes involved in lipid metabolism (such as lipoprotein lipase).
For example, a 2017 animal study published in Journal of Functional Foods found that isoquercetin supplementation reduced triglyceride levels in mice fed a high-fat diet. The authors attributed these effects to isoquercetin's ability to improve oxidative stress and regulate genes involved in lipid synthesis. Additionally, some clinical studies with quercetin (the aglycone of isoquercetin) have reported modest reductions in serum triglycerides in humans, though results are inconsistent and direct human evidence for isoquercetin remains limited.
Overall, the scientific evidence for isoquercetin in lowering triglycerides is preliminary and mostly based on preclinical models, with limited direct evidence from human trials. Thus, while there is a scientific rationale and some supportive data, the quality and quantity of evidence are not yet strong, resulting in a moderate-low evidence rating.
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anthocyanins
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artichoke
ashwagandha
astaxanthin
banaba
beet
berberine
bergamot
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black currant
black garlic
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black tea
blueberry
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canola oil
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coleus forskohlii
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EPA (eicosapentaenoic acid)
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oleic acid
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stevia
strawberry
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