Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lovastatin is a member of the statin class of drugs, primarily used to lower cholesterol levels, specifically low-density lipoprotein cholesterol (LDL-C). However, statins, including lovastatin, also have modest effects on lowering triglyceride levels. Clinical studies have consistently shown that lovastatin can reduce triglyceride concentrations, particularly in patients with elevated baseline triglycerides. The typical reduction in triglyceride levels with lovastatin is in the range of 10-25%, depending on the dose and the initial triglyceride concentration.

The mechanism by which lovastatin lowers triglycerides is not completely direct. By inhibiting HMG-CoA reductase, lovastatin reduces cholesterol synthesis in the liver, leading to increased clearance of LDL and, to a lesser extent, very low-density lipoprotein (VLDL), which carries triglycerides. This results in a secondary decrease in plasma triglyceride levels. The effect is generally less pronounced than with fibrates or omega-3 fatty acids, which are considered primary treatments for hypertriglyceridemia, but statins are commonly used in mixed dyslipidemia (where both cholesterol and triglycerides are elevated).

Clinical guidelines recommend statins like lovastatin primarily for LDL reduction, but they are also indicated when triglycerides are mildly to moderately elevated, especially if cardiovascular risk is high. Thus, while lovastatin is not the most potent triglyceride-lowering agent, there is solid scientific evidence to support its use for this purpose, albeit with a moderate effect size.

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More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
anchovies
anthocyanins
apple
arjun tree
artichoke
ashwagandha
astaxanthin
banaba
beet
berberine
bergamot
Beta-Glucan
black currant
black garlic
sesame
black tea
blueberry
broccoli
calamari oil
canola oil
catechins
chia seed
chokeberry
choline
coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
daidzin
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
flaxseed
fruit and vegetable blend (proprietary)
genistein
genistin
glucomannan
grape
grapefruit
green tea
guar gum
guggul
hawthorn
hesperetin
hibiscus
inulin
knotweed
kale
krill oil
kudzu
l-carnitine
l-taurine
lecithin
lignans
linoleic acid (LA)
lycopene
mackerel
magnesium
maqui berry
matcha
naringin
niacin (vitamin B3)
oat
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
pantethine
perilla
phospholipids
pine bark
plant sterols
pomegranate
pomelo
quercetin
quinoa
red yeast rice
resveratrol
safflower oil
sardines
silymarin
black ginger
soybean
spirulina
sterols
stevia
strawberry
tocotrienols
tomato
trans-pterostilbene
trimethylglycine (TMG)
almond fruit
ubiquinol
vegetable and fruit blend (proprietary)
vitamin C
mulberry
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
lingzhi
sunflower
yerba mate
goji berry
amaranth
kidney beans
cocoa
AMP-activated protein kinase (AMPK)
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-hydroxyisoleucine
Arjuna
Aronia melanocarpa
Avocado
Ascophyllum nodosum
Alpha-Lipoic Acid
Astragaloside
Adzuki bean
Ampelopsin
Alpha phytosterol
Algal protein
Arjunic Acid
Algalin
Alliin
Arabinoxylan
Argan nut oil
alpha Methyl Tetradecylthioacetic Acid
Arjunolic acid
Buglossoides arvensis
Brutieridin
Brassica
Brazil nut
Buckwheat
Bottle gourd
California chia
Cardarine
Chitosan
Camelina Oil
Cod Liver Oil
Coriander
Cashew
Cyanidin
chlorogenic acid
Chinese Fleeceflower
Cynarin
Cruciferous
Capsiate
Chitin-Glucan Complex
Calanus finmarchicus
Crocetin
corosolic acid
Crypthecodinium
Carnosic acid
Docosahexaenoic Acid
Danshen
Daidzein
Dragon Fruit
Diosgenin
Eriocitrin
Emblicanin
Eicosatetraenoic acid
Eicosapentaenoic Acid
Echium
Ecklonia
Flammulina velutipes
Isoflavones
Pistachio
Soy Protein
walnut

Other health conditions supported by Lovastatin

Angina
Arteriosclerosis
Cancer (prevention)
Cardiovascular Disease
Cholesterol (high)
Fat Metabolism (poor)
Metabolic Syndrome
Strokes
Triglycerides (high)

Products containing Lovastatin

We currently have no products on Vitabase that contain this ingredient.