Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lycopene, a carotenoid found predominantly in tomatoes, has been investigated for its potential effects on lipid metabolism, including triglyceride levels. Several clinical and observational studies suggest that lycopene supplementation or high dietary intake may have a modest triglyceride-lowering effect, but the overall strength of evidence is limited and somewhat inconsistent. A few randomized controlled trials (RCTs) have reported reductions in triglyceride levels following lycopene supplementation, often in the range of 10–15%, especially in populations with elevated baseline triglycerides or metabolic syndrome. Proposed mechanisms include lycopene’s antioxidant properties, modulation of lipid metabolism genes, and anti-inflammatory effects, which may collectively contribute to improved lipid profiles. However, not all studies have found significant changes in triglycerides, and meta-analyses generally conclude that while lycopene may benefit total and LDL cholesterol, its effect on triglycerides is less pronounced and not always statistically significant. Most clinical guidelines do not currently recommend lycopene specifically for hypertriglyceridemia due to insufficient high-quality evidence. Nonetheless, lycopene-rich diets are associated with overall cardiovascular benefits, which may indirectly support healthy triglyceride levels as part of a broader dietary pattern. In summary, there is some scientific evidence, though not robust, supporting lycopene’s use for high triglycerides. It is best viewed as a supplementary component of a heart-healthy diet rather than a primary treatment for hypertriglyceridemia.

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