Relationship: Triglycerides (high) and niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacin (vitamin B3) is scientifically validated as a therapy to lower high triglycerides. Its use is supported by decades of clinical research and clinical practice guidelines. Niacin works by inhibiting hepatic diacylglycerol acyltransferase-2, which reduces the synthesis of very-low-density lipoprotein (VLDL), a precursor to triglycerides. As a result, niacin significantly lowers serum triglyceride levels—often by 20-50%—and can also modestly increase HDL (good cholesterol) and lower LDL (bad cholesterol). Numerous randomized controlled trials, including large studies such as the Coronary Drug Project and the AIM-HIGH trial, have shown that niacin effectively reduces triglyceride levels in patients with hyperlipidemia and mixed dyslipidemia.

However, while niacin is effective for lipid modification, more recent studies have called into question its benefit on cardiovascular outcomes when added to statin therapy, especially given its side-effect profile (notably flushing, glucose intolerance, and hepatotoxicity). Despite this, its triglyceride-lowering efficacy is not disputed, and it remains an option for selected patients unable to tolerate first-line medications or with particularly severe hypertriglyceridemia at risk of pancreatitis. In summary, niacin’s use to reduce high triglycerides is strongly supported by scientific evidence, though its place in therapy is now more selective due to side effects and newer alternatives.

More about niacin (vitamin B3)
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Other ingredients used for Triglycerides (high)

akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
anchovies
anthocyanins
apple
arjun tree
artichoke
ashwagandha
astaxanthin
banaba
beet
berberine
bergamot
Beta-Glucan
black currant
black garlic
sesame
black tea
blueberry
broccoli
calamari oil
canola oil
catechins
chia seed
chokeberry
choline
coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
daidzin
DHA (docosahexaeonic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fish protein
flaxseed
fruit and vegetable blend (proprietary)
genistein
genistin
glucomannan
grape
grapefruit
green tea
guar gum
guggul
hawthorn
hesperetin
hibiscus
inulin
knotweed
kale
krill oil
kudzu
l-carnitine
l-taurine
lecithin
lignans
linoleic acid (LA)
lycopene
mackerel
magnesium
maqui berry
matcha
naringin
niacin (vitamin B3)
oat
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
pantethine
perilla
phospholipids
pine bark
plant sterols
pomegranate
pomelo
quercetin
quinoa
red yeast rice
resveratrol
safflower oil
sardines
silymarin
black ginger
soybean
spirulina
sterols
stevia
strawberry
tocotrienols
tomato
trans-pterostilbene
trimethylglycine (TMG)
almond fruit
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vegetable and fruit blend (proprietary)
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4-hydroxyisoleucine
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Ascophyllum nodosum
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Adzuki bean
Ampelopsin
Alpha phytosterol
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Arabinoxylan
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alpha Methyl Tetradecylthioacetic Acid
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chlorogenic acid
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corosolic acid
Crypthecodinium
Carnosic acid
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Daidzein
Dragon Fruit
Diosgenin
Eriocitrin
Emblicanin
Eicosatetraenoic acid
Eicosapentaenoic Acid
Echium
Ecklonia
Flammulina velutipes
Isoflavones
Pistachio
Soy Protein
walnut

Other health conditions supported by niacin (vitamin B3)

Alcoholism
Arteriosclerosis
Burning Feet or Hands
Cholesterol (high)
Circulation (poor)
Fatty Liver Disease
Memory and Brain Function
Migraine
Schizophrenia
Triglycerides (high)

Products containing niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by niacin (vitamin B3)

Products containing niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)