Relationship: Triglycerides (high) and niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)

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Synopsis
Other ingredients for this health condition
Other health conditions supported by this ingredient
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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Niacin (vitamin B3) is scientifically validated as a therapy to lower high triglycerides. Its use is supported by decades of clinical research and clinical practice guidelines. Niacin works by inhibiting hepatic diacylglycerol acyltransferase-2, which reduces the synthesis of very-low-density lipoprotein (VLDL), a precursor to triglycerides. As a result, niacin significantly lowers serum triglyceride levels—often by 20-50%—and can also modestly increase HDL (good cholesterol) and lower LDL (bad cholesterol). Numerous randomized controlled trials, including large studies such as the Coronary Drug Project and the AIM-HIGH trial, have shown that niacin effectively reduces triglyceride levels in patients with hyperlipidemia and mixed dyslipidemia.

However, while niacin is effective for lipid modification, more recent studies have called into question its benefit on cardiovascular outcomes when added to statin therapy, especially given its side-effect profile (notably flushing, glucose intolerance, and hepatotoxicity). Despite this, its triglyceride-lowering efficacy is not disputed, and it remains an option for selected patients unable to tolerate first-line medications or with particularly severe hypertriglyceridemia at risk of pancreatitis. In summary, niacin’s use to reduce high triglycerides is strongly supported by scientific evidence, though its place in therapy is now more selective due to side effects and newer alternatives.

More about Niacin (vitamin B3)
More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
4-hydroxyisoleucine
Adzuki bean
Akkermansia muciniphila
algal oil
Algal protein
Algalin
Alliin
Almond fruit
Alpha methyl tetradecylthioacetic acid
Alpha phytosterol
alpha-linolenic acid (ALA)
alpha-lipoic acid
amaranth
AMP-activated protein kinase (AMPK)
ampelopsin
anchovies
anthocyanins
apple
arabinoxylan
argan nut oil
arjun tree
arjuna
arjunic acid
Arjunolic acid
Aronia melanocarpa
artichoke
Ascophyllum nodosum
ashitaba
ashwagandha
astaxanthin
astragaloside
avocado
banaba
beet
berberine
bergamot
beta-glucan
black currant
black garlic
black ginger
black tea
blueberry
bottle gourd
Brassica
Brazil nut
broccoli
brutieridin
Buckwheat
Buglossoides arvensis
calamari oil
Calanus finmarchicus
California chia
camelina oil
capsiate
cardarine
carnosic acid
cashew
catechins
chia seed
Chinese fleeceflower
Chitin-Glucan Complex
chitosan
chlorogenic acid
chokeberry
choline
cocoa
cod liver oil
Coleus forskohlii
conjugated linoleic acid (CLA)
cordyceps
coriander
corosolic acid
crocetin
cruciferous
Crypthecodinium
cyanidin
cynarin
daidzein
daidzin
danshen
DHA (docosahexaenoic acid)
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
diosgenin
docosahexaenoic Acid
DPA (docosapentaenoic acid)
dragon fruit
Echium
Ecklonia
eicosapentaenoic acid
Eicosatetraenoic acid
emblicanin
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
eriocitrin
fish
fish protein
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flavanols
flavanones
flaxseed
fo-ti
fruit and vegetable blend (proprietary)
fucosterol
fucoxanthin
genistein
genistin
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glucomannan
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goji berry
grape
grapefruit
green tea
guar gum
guggul
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Gypenoside
hawthorn
hesperetin
hibiscus
horse gram
hydroxycinnamic acid
hydroxytyrosol
inulin
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isoflavones
jiaogulan
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kidney beans
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knotweed
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lecithin
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linoleic acid (LA)
linseed oil
lupin
lycopene
macadamia
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mangiferin
maqui berry
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Matcha
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Millet
Monacolin
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oleanolic acid
oleic acid
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olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oolong tea
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oyster mushroom
palmitoleic acid
pantethine
perilla
Phaeophyceae
phospholipids
Phytoestrogens
Piceid
pine bark
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plant sterols
Pleurotus eryngii
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polychitosamine
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polymethoxylated flavones
polyunsaturated fat
pomegranate
pomelo
pu-er tea
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punicalagins
purple tea
quercetin
quinoa
rapeseed oil
red yeast
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safflower oil
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silymarin
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tocotrienols
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ubiquinol
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vegetable and fruit blend (proprietary)
vegetable oil
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vitamin C
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Other health conditions supported by Niacin (vitamin B3)

Alcoholism
Arteriosclerosis
Burning Feet or Hands
Cholesterol (high)
Circulation (poor)
Fatty Liver Disease
Memory and Brain Function
Migraine
Schizophrenia
Triglycerides (high)

Products containing Niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by Niacin (vitamin B3)

Products containing Niacin (vitamin B3)

Health Concerns

Brands

Evidence supporting the use of: Niacin (vitamin B3)For the health condition: Triglycerides (high)

Table of Contents

Synopsis

Other ingredients used for Triglycerides (high)

Other health conditions supported by Niacin (vitamin B3)

Products containing Niacin (vitamin B3)

Evidence supporting the use of: Niacin (vitamin B3)
For the health condition: Triglycerides (high)