Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Perilla (Perilla frutescens), particularly its seeds and oil, has been investigated in scientific studies for its potential lipid-lowering effects, including a possible benefit on elevated triglyceride levels. Perilla oil is rich in alpha-linolenic acid (ALA), an omega-3 fatty acid, which is thought to have cardiovascular benefits similar to those of fish oil. Several animal studies have demonstrated that supplementation with perilla oil can reduce serum triglyceride levels, possibly through modulation of lipid metabolism and improvement of hepatic lipid profiles.

Human data is more limited but suggests a trend in the same direction. For instance, small clinical trials have shown that diets enriched with perilla oil (compared to diets high in saturated fats) may result in reduced triglyceride levels and improved lipid profiles. However, these studies are often small, short-term, or confounded by other dietary changes. The mechanism is believed to be related to the conversion of ALA to longer-chain omega-3 fatty acids, which are known to lower triglycerides, though this conversion rate is relatively low in humans.

Traditional Asian medicine has used perilla for various purposes, but there is little direct traditional evidence supporting its use specifically for triglyceride reduction. Thus, the justification for using perilla to support healthy triglyceride levels is primarily based on emerging but limited scientific evidence rather than a long history of traditional use. Larger, higher-quality clinical trials are needed to confirm its efficacy and establish dosing guidelines.

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