Evidence supporting the use of: Phenolic diterpenes (unspecified)
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phenolic diterpenes, particularly those found in herbs like rosemary (Rosmarinus officinalis), such as carnosic acid and carnosol, have been the subject of some scientific research regarding their impact on lipid metabolism, including triglyceride levels. Several animal studies suggest that these compounds may help lower plasma triglyceride concentrations, potentially by modulating lipid absorption, enhancing fat oxidation, or altering gene expression related to lipid metabolism. For instance, studies in rodents have demonstrated that supplementation with rosemary extracts rich in phenolic diterpenes can reduce serum triglyceride levels as well as total cholesterol. Some proposed mechanisms include activation of AMP-activated protein kinase (AMPK) and inhibition of pancreatic lipase, both of which are pathways relevant to fat metabolism.

However, the evidence in humans is limited. A few small-scale clinical trials have explored the effects of rosemary extract supplementation on lipid profiles, with mixed results. Some reported modest reductions in triglyceride levels, while others found no significant effect. Most studies have methodological limitations such as short duration, small sample sizes, or lack of controls. As a result, while there is preliminary scientific support from preclinical models and some human data, these findings are not strong or consistent enough to warrant a higher evidence score or recommend phenolic diterpenes as a standard treatment for high triglycerides. More rigorous clinical trials are necessary to establish efficacy and safety in humans.

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Products containing Phenolic diterpenes (unspecified)

We currently have no products on Vitabase that contain this ingredient.