Evidence supporting the use of: Polydatin
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polydatin is a natural precursor of resveratrol, found primarily in the plant Polygonum cuspidatum (Japanese knotweed). There is emerging scientific interest in its potential to support healthy lipid metabolism, including the management of high triglyceride levels. Several animal studies have demonstrated that polydatin supplementation can reduce serum triglyceride levels, likely due to its antioxidant and anti-inflammatory properties and its influence on lipid metabolism pathways. For example, studies in hyperlipidemic rats have shown that polydatin administration leads to significant reductions in serum triglycerides, potentially via modulation of the PPAR-α pathway and upregulation of genes involved in fatty acid oxidation.

However, direct evidence in humans remains limited. A small number of clinical studies involving polydatin (or resveratrol-rich extracts containing polydatin) suggest possible benefits for overall lipid profiles, but these studies are preliminary, often with small sample sizes and varying methodologies. No large-scale, high-quality randomized controlled trials have established polydatin as a mainstream treatment for elevated triglycerides in humans.

In summary, while there is some preclinical scientific evidence supporting polydatin’s use in lowering triglycerides, clinical validation is insufficient. As such, the evidence is rated as 2 out of 5, reflecting promising animal data but limited and inconclusive data in humans.

More about Polydatin
More about Triglycerides (high)

Other ingredients used for Triglycerides (high)

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algal oil
alpha-linolenic acid (ALA)
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anthocyanins
apple
arjun tree
artichoke
ashwagandha
astaxanthin
banaba
beet
berberine
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black garlic
sesame
black tea
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broccoli
calamari oil
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daidzin
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DPA (docosapentaenoic acid)
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epigallocatechin gallate (EGCG)
fish protein
flaxseed
fruit and vegetable blend (proprietary)
genistein
genistin
glucomannan
grape
grapefruit
green tea
guar gum
guggul
hawthorn
hesperetin
hibiscus
inulin
knotweed
kale
krill oil
kudzu
l-carnitine
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lecithin
lignans
linoleic acid (LA)
lycopene
mackerel
magnesium
maqui berry
matcha
naringin
niacin (vitamin B3)
oat
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-7 fatty acids
omega-9 fatty acids
oyster mushroom
palmitoleic acid
pantethine
perilla
phospholipids
pine bark
plant sterols
pomegranate
pomelo
quercetin
quinoa
red yeast rice
resveratrol
safflower oil
sardines
silymarin
black ginger
soybean
spirulina
sterols
stevia
strawberry
tocotrienols
tomato
trans-pterostilbene
trimethylglycine (TMG)
Almond fruit
ubiquinol
vegetable and fruit blend (proprietary)
vitamin C
mulberry
zinc
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jiaogulan
lingzhi
sunflower
yerba mate
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kidney beans
cocoa
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4-hydroxyisoleucine
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Products containing Polydatin

We currently have no products on Vitabase that contain this ingredient.