Sacha Inchi protein is derived from the seeds of Plukenetia volubilis, a plant native to the Amazon rainforest. The seeds are notably high in protein, fiber, and particularly omega-3 fatty acids (mainly alpha-linolenic acid, ALA). Several small clinical studies and animal experiments have investigated the effects of Sacha Inchi oil—and, to a lesser extent, the protein—on blood lipid profiles, including triglycerides. For instance, a randomized controlled trial published in 2011 in Clinical Nutrition found that supplementation with Sacha Inchi oil in humans led to a modest reduction in triglyceride levels, likely due to its high ALA content. While most research has focused on the oil rather than the isolated protein, Sacha Inchi protein powders often retain some of the seed's fatty acids and may contribute to lipid modulation.

However, the evidence remains limited: studies are few, sample sizes are generally small, and there is a lack of robust, long-term clinical trials specifically examining Sacha Inchi protein (as distinct from the oil) for hypertriglyceridemia. The mechanism is biologically plausible, since increased intake of plant-based omega-3s and fiber are known to help lower triglyceride levels. Nonetheless, more research is needed to confirm efficacy, optimal dosage, and long-term safety. Currently, the use of Sacha Inchi protein for high triglycerides is supported by preliminary scientific studies, but the overall quality and quantity of evidence is low to moderate.