Evidence supporting the use of: Salvianolic acid
For the health condition: Triglycerides (high)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salvianolic acid, a polyphenolic compound primarily isolated from the herb Salvia miltiorrhiza (Danshen), has been investigated in both animal and limited human studies for its cardiovascular benefits, including effects on lipid metabolism. Several preclinical studies in rodents have demonstrated that salvianolic acid B can reduce serum triglyceride levels, likely through antioxidant activity, improved endothelial function, and modulation of lipid metabolic pathways. For instance, animal models of hyperlipidemia have shown decreased triglycerides and cholesterol with salvianolic acid treatment, attributed to upregulation of hepatic lipid metabolism genes and reduction of oxidative stress.

However, the direct evidence from human clinical trials is sparse. Most studies have used Danshen extracts containing multiple active components, making it difficult to attribute effects specifically to salvianolic acid. A few small clinical trials and meta-analyses of Danshen-based formulas report modest reductions in triglycerides and other lipid parameters, but methodological limitations and heterogeneity of preparations limit the certainty of these findings. Thus, while there is plausible biological rationale and supportive animal data, the clinical evidence is low in quality and quantity, meriting a modest evidence score.

In summary, salvianolic acid’s use to support high triglycerides is primarily supported by preclinical research and limited, low-quality clinical data. More rigorous human trials with purified salvianolic acid are needed to confirm its efficacy and safety for this indication.

More about Salvianolic acid
More about Triglycerides (high)

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Products containing Salvianolic acid

We currently have no products on Vitabase that contain this ingredient.