Evidence supporting the use of: Allantoin
For the health condition: Ulcerations (external)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Allantoin is a compound commonly found in various plants (such as comfrey) and is also produced synthetically. It is widely used in topical formulations for skin protection and wound healing. The scientific basis for its use in treating external ulcerations primarily comes from preclinical and limited clinical data demonstrating its ability to promote cell proliferation, epithelialization, and wound healing. Mechanistically, allantoin is known to act as a keratolytic agent, facilitating the removal of dead tissue and stimulating the growth of new, healthy tissue. Several in vitro and animal studies have shown allantoin's positive effects on wound repair and tissue regeneration. Moreover, some clinical studies and case reports suggest that topical allantoin-containing preparations can accelerate healing of superficial wounds, minor burns, and ulcerations by maintaining a moist environment and reducing irritation. However, the evidence base is not robust. There are relatively few well-designed, large-scale clinical trials specifically evaluating allantoin's efficacy in treating external ulcerations in humans. Most of the available clinical evidence comes from studies of combination products, making it difficult to isolate allantoin’s effect. The U.S. FDA recognizes allantoin as a skin protectant for minor wounds, but not specifically for ulcerations. In summary, while there is scientific rationale and some supporting data for its use in external ulcerations, the overall quality and quantity of evidence is limited, resulting in a moderate-low evidence rating.

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Products containing Allantoin

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