Evidence supporting the use of: Celandine
For the health condition: Ulcerations (external)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Celandine (Chelidonium majus) has a long history of traditional use for the treatment of external ulcerations and skin conditions. Historical texts from European herbal medicine, dating back to the Middle Ages, describe the topical application of celandine sap to treat skin ulcers, warts, and other dermatological issues. The latex-like sap of the plant contains a mixture of alkaloids (such as chelidonine, sanguinarine, and chelerythrine), which were believed to have antimicrobial and anti-inflammatory properties. In folk medicine, the sap was often directly applied to skin lesions in hopes of promoting healing and preventing infection. However, scientific evidence supporting these traditional uses is limited. Some in vitro and animal studies have demonstrated antimicrobial and anti-inflammatory effects of celandine extracts, but robust clinical trials in humans are lacking, particularly for external ulcerations. Furthermore, the topical use of celandine can cause skin irritation, allergic reactions, or even chemical burns in sensitive individuals. Modern herbalists may still reference its traditional applications, but most medical authorities caution against its unregulated use due to potential toxicity. In summary, the use of celandine for external ulcerations is primarily supported by historical and traditional practices, with limited scientific validation.

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