Evidence supporting the use of: Comfrey
For the health condition: Ulcerations (external)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Comfrey (Symphytum officinale) has a long history of traditional use for the external treatment of skin ulcerations, wounds, and other skin conditions. The roots and leaves of comfrey contain allantoin, a compound believed to promote cell proliferation and tissue regeneration. Historical records from European herbalism, dating back to the Middle Ages, describe the use of comfrey poultices and salves for promoting the healing of ulcers, bruises, and other external injuries. Folk medicine has valued comfrey for its purported ability to "knit" tissues together, earning it the nickname "knitbone."

Modern scientific studies on comfrey's effectiveness for external ulcerations are limited, but some clinical and laboratory research suggests that topical preparations containing comfrey extract may support wound healing and reduce inflammation. Randomized controlled trials have demonstrated benefits for other skin conditions such as abrasions and sprains, but direct evidence for ulcerations is less robust. Importantly, topical comfrey is still used in some European countries, though internal use is discouraged due to safety concerns about pyrrolizidine alkaloids.

Overall, comfrey's use for external ulcerations is primarily justified by traditional herbal practice, with moderate support from limited scientific studies indicating potential wound healing effects. Safety considerations mean that only externally-applied, PA-free (pyrrolizidine alkaloid-free) products are recommended.

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