Dragon's Blood, a red resin obtained from various plant species such as Daemonorops draco and Croton lechleri, has been used traditionally in many cultures for the treatment of external ulcerations and wounds. Historical records from Traditional Chinese Medicine, as well as indigenous practices in South America, document its topical application to accelerate wound healing, stop bleeding, and protect against infections. The resin was often applied directly to ulcers or sores, and its use as a styptic and vulnerary agent was well-known.

The traditional rationale is based on its observed ability to form a protective barrier over wounds and its reputed antimicrobial and anti-inflammatory properties. Early European explorers and herbalists also noted its use among local populations. In modern times, some laboratory and animal studies have suggested that extracts from Dragon's Blood may possess antimicrobial, anti-inflammatory, and wound-healing activities, possibly due to compounds such as taspine and phenolic constituents. However, robust clinical trials in humans are limited, and thus the strongest support remains traditional rather than scientific. Despite this, the historical and ethnobotanical record for external ulcerations is substantial.