Polyvinylpyrrolidone (PVP), often referred to as povidone, is primarily used in the treatment of external ulcerations as a component of povidone-iodine formulations. Povidone-iodine is a well-established antiseptic that combines iodine with polyvinylpyrrolidone, which acts as a carrier and controls the release of free iodine. The antiseptic properties of povidone-iodine have been extensively documented in the scientific literature, including its use in managing wounds, burns, and ulcerations to prevent infection and promote healing. Clinical studies and reviews have demonstrated that povidone-iodine preparations can reduce microbial load in chronic ulcers and support wound healing, although some studies have noted concerns about cytotoxicity with prolonged use on open wounds.

Importantly, polyvinylpyrrolidone itself does not have intrinsic healing or antimicrobial properties; its role is to solubilize and deliver iodine in a sustained manner, which enhances the safety and efficacy profile of iodine for topical wound care. The use of povidone-iodine in ulcer management is included in several clinical guidelines. However, PVP alone (without iodine) is not typically used for ulcerations, and its benefit is indirect, serving as a vehicle for the active antiseptic agent. Thus, the scientific evidence supporting the use of PVP-containing formulations (specifically povidone-iodine) for ulcerations is moderate, meriting a rating of 3.