Povidone, most commonly encountered as Povidone-iodine (PVP-I), is widely used in the management of external ulcerations, including wounds and skin ulcers. The justification for its use is grounded in scientific evidence. Povidone-iodine is a broad-spectrum antiseptic with proven efficacy against bacteria, viruses, and fungi, and it is valued for its ability to reduce the microbial load in wounds, thereby minimizing the risk of infection and supporting healing.

Several studies and clinical guidelines support the use of povidone-iodine for wound care, including treatment of ulcerations. For example, a 2017 review in the journal International Wound Journal highlighted that povidone-iodine shows effectiveness in promoting wound healing and preventing infection without significant cytotoxicity when used at appropriate concentrations. Furthermore, randomized controlled trials have demonstrated that povidone-iodine dressings can accelerate healing in chronic ulcers and decrease bacterial colonization compared to standard saline dressings.

However, some caution is advised due to potential cytotoxic effects at higher concentrations and possible iodine absorption, especially in large or chronic wounds. Overall, the substantial body of scientific literature, along with its inclusion in clinical protocols for wound and ulcer management, justifies the use of povidone-iodine for external ulcerations, with moderate to strong evidence supporting its efficacy in this context.