Relationship: Ulcerations (external) and protease

Evidence supporting the use of: Protease
For the health condition: Ulcerations (external)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proteases are enzymes that break down proteins and have been used in the management of external ulcerations, such as chronic wounds and ulcers, primarily due to their debriding properties. Scientific studies and clinical experience support the use of proteolytic enzymes, including those derived from microorganisms (like subtilisin) or plants (such as papain and bromelain), in wound care. Their primary role is to aid in the removal of necrotic tissue (debridement), which is essential for preparing the wound bed and promoting healing. Enzymatic debridement is especially valuable when surgical or autolytic debridement is not feasible or when a selective, less invasive approach is needed. Proteases help by digesting devitalized tissue without damaging viable cells, potentially reducing infection risk and supporting granulation.

Several studies and clinical guidelines acknowledge the benefits of topical protease preparations in wound management, and products containing proteolytic enzymes are widely used in clinical practice for treating pressure ulcers, venous leg ulcers, and diabetic foot ulcers. However, the overall strength and quality of evidence vary, and while many reports and case series describe positive outcomes, there remains a need for more high-quality randomized controlled trials to firmly establish efficacy and optimal usage protocols. Nonetheless, the scientific rationale and clinical experience justify their use, particularly in cases where other debridement methods are contraindicated.

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Other health conditions supported by protease

Abrasions
Bruises (healing)
Burns and Scalds
Cancer Treatment (reducing side effects)
Congestion (lymphatic)
Cuts
Edema
Exercise
Inflammation
Injuries
Pain (general remedies for)
Scratches and Abrasions
Surgery (healing from)
Tendonitis
Ulcerations (external)
Wounds and Sores

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Evidence supporting the use of: Protease
For the health condition: Ulcerations (external)

Table of Contents

Synopsis

Other ingredients used for Ulcerations (external)

Other health conditions supported by protease

Products containing protease

Health Concerns

Brands

Evidence supporting the use of: ProteaseFor the health condition: Ulcerations (external)

Table of Contents

Synopsis

Other ingredients used for Ulcerations (external)

Other health conditions supported by protease

Products containing protease

Evidence supporting the use of: Protease
For the health condition: Ulcerations (external)