Evidence supporting the use of: Apigenin
For the health condition: Ulcers

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apigenin, a flavonoid found in various plants such as chamomile, parsley, and celery, has been investigated for its gastroprotective effects, particularly in the context of ulcers. Preclinical studies, primarily in animal models, have demonstrated that apigenin may help prevent or reduce gastric ulcer formation. The proposed mechanisms include its antioxidant activity, anti-inflammatory effects, and its ability to enhance mucosal defenses. For example, several rat studies have shown that apigenin administration reduces the severity of ulcers induced by ethanol or non-steroidal anti-inflammatory drugs (NSAIDs), likely by decreasing oxidative stress and suppressing pro-inflammatory cytokine production (see: Salehi et al., Phytotherapy Research, 2019). Additionally, apigenin has been observed to inhibit gastric acid secretion and increase mucus production, which contributes to mucosal protection. However, these findings are largely limited to laboratory and animal research. There is currently a lack of robust clinical trials in humans assessing apigenin's effectiveness for ulcer prevention or treatment. Traditional use of apigenin-containing herbs like chamomile for digestive complaints exists, but the specific use of isolated apigenin for ulcers is backed by preclinical, not clinical, evidence. Therefore, while there is some scientific rationale and foundational evidence from animal studies, direct clinical validation in humans is lacking, resulting in a low-to-moderate evidence rating.

More about Apigenin
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cutch
akkermansia muciniphila
alfalfa
aloe vera
annatto
anthocyanins
apple
apricot
arjun tree
astragalus
bacillus coagulans
bacillus subtilis
bamboo
barberry
barley
berry flavor
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bifidobacterium bifidum
bifidobacterium lactis
bifidobacterium longum
bilberry
black currant
black garlic
bupleurum falcatum
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caterpillar mushroom
cauliflower
chaga mushroom
champignon
chicory
colostrum
curcumin
cuspidatum root
d-alpha tocopherol
diallyl disulfide (DADS)
dong quai root
melon
epigallocatechin gallate (EGCG)
fennel
flaxseed
gentian root
grape
green banana
green tea
heartwood
hesperetin
Indian gum arabic tree
honeysuckle
knotweed
Japanese sophora
jujube
l-carnosine
l-cysteine
l-glutathione
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus casei
lactobacillus fermentum
lactobacillus gasseri
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus salivarius
lactococcus lactis
licorice root
luteolin
mango
mangosteen
marshmallow
melatonin
methylmethionine sulfonium chloride (vitamin U)
mint
n-acetyl-glucosamine
oat
okra
oleanolic acid
olive
pectin
perilla
phospholipids
pine bark
platycodon root
pomegranate
pomelo
pumpkin
quail egg
quercetin
redcurrant
rehmannia glutinosa
resveratrol
rhubarb root
rose hips
sage
slippery elm bark
spirulina
sulforaphane glucosinolate
tocotrienols
tributyrin
vitamin C
watercress
wheat grass
whey protein
mulberry
zinc
bentonite
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yellow root
cardamom
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alpinia galangal
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pistacia integerrima gall
holarrhena antidysenterica
fumaria parviflora
picrorhiza kurroa
rubia cordifolia
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bee pollen
blessed thistle
lingzhi
yarrow
prickly ash
elecampane
broomrape
flowering quince
dogwood
lotus seed
birch
sodium alginate
sheep's sorrel
queen of the meadow
caraway
purslane
wood betony
biota seed
goji berry
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alginic acid
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acacia
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Abrus
Alchornea
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Amomum
Asarum heterotropoides
Albizia
Alchemilla
Asafoetida
Aucubin
Anserina
Asam gelugor
Astragaloside
Arrowroot
anthocyanidins
Andrographis
Alsonia scholaris
Agrimonia pilosa
Acemannan
Algin
Anemarrhena
Abuta
Alstonia macrophylla
Amor seco
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Arisaema
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Buttermilk
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Bai Ji
Baliospermum
Baphicacanthus cusia
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bergenin
Betulinic acid
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Boswellic Acid
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Baicalein
Bael
Bloodroot
Butternut
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banana
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Bifidobacteria
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bacoside
Baicalin
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Belamcanda
Bergenia
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Caffeic Acid
Cumin
Centaury
Centella triterpenes
Casearia esculenta
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Carqueja
Catalpol
Chebulic acid
Coriander
Clerodendrum phlomidis
Carvacrol
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Cyanidin
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Cinidium
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Colombo
Corktree
Cubeb
C-Phycocyanin
Carob
Cabbage
Cranesbill
Carlina
Calamus
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Chebulinic acid
Corilagin
Cynodon dactylon
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Chiococca alba
Cynanchum
Casearia sylvestris
Carnosic acid
Didymocarpus
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Date
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epicatechin
Emblicanin
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Emodin
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Products containing Apigenin

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