Evidence supporting the use of: Astragaloside IV
For the health condition: Ulcers

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Astragaloside IV and Ulcers: Scientific Evidence

Astragaloside IV is a primary active compound extracted from Astragalus membranaceus, a traditional medicinal herb. While Astragalus itself has a long-standing history in traditional Chinese medicine for supporting general gastrointestinal health, the specific use of astragaloside IV for ulcer treatment is based on more recent preclinical research rather than ancient tradition.

Several animal studies have investigated the effects of astragaloside IV on gastric and duodenal ulcers. For example, research published in scientific journals has demonstrated that astragaloside IV can reduce the area of gastric ulcers in rats induced by ethanol or stress. The proposed mechanisms include enhancement of mucosal defense, reduction of inflammation, and promotion of mucosal healing. Astragaloside IV appears to downregulate pro-inflammatory cytokines (such as TNF-α and IL-6) and reduce oxidative stress in ulcer models. Additionally, it has been shown to increase the production of protective gastric mucins and promote angiogenesis, which can aid ulcer repair.

However, it is important to note that the current body of evidence comes primarily from animal and cell-based studies. There are no robust clinical trials in humans evaluating the efficacy or safety of astragaloside IV for ulcer treatment. Thus, while there is a scientific rationale supported by preclinical data, the overall evidence remains limited (score: 2/5) and further research, especially in humans, is required to establish its therapeutic role.

More about Astragaloside IV
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gentian root
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heartwood
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Products containing Astragaloside IV

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