Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Curcumin, the main active compound in turmeric (Curcuma longa), has garnered scientific interest for its potential role in supporting or treating ulcers, particularly peptic and gastric ulcers. Multiple preclinical studies have demonstrated that curcumin exhibits anti-inflammatory, antioxidant, and anti-ulcerogenic properties. Mechanistically, curcumin has been shown to inhibit gastric acid secretion, increase the secretion of gastric mucus, and enhance mucosal defense, which are beneficial in ulcer healing. Animal studies suggest curcumin can reduce ulcer formation induced by ethanol, stress, or NSAIDs. Furthermore, curcumin's inhibition of Helicobacter pylori, a bacterium implicated in many gastric ulcers, has been observed in vitro and in some animal models.

Human clinical evidence, though promising, is less robust. A few small clinical trials have reported that curcumin supplementation may improve symptoms and promote healing in patients with peptic ulcers. For example, a 1989 study from Thailand found that 76% of patients experienced ulcer healing after 12 weeks of curcumin therapy. However, sample sizes have been small, methodologies varied, and studies are often limited by lack of blinding or placebo controls.

Overall, while traditional medicine has used turmeric for digestive complaints, there is a growing body of scientific evidence—primarily from preclinical and small clinical studies—supporting curcumin’s potential benefit in ulcer management. Nevertheless, large, high-quality randomized controlled trials are needed to firmly establish efficacy and safety in this context.

More about curcumin
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