Evidence supporting the use of: L-glutathione
For the health condition: Ulcers

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutathione has some scientific basis for its potential use in supporting the treatment or prevention of ulcers, particularly gastric ulcers. Glutathione is a tripeptide composed of glutamine, cysteine, and glycine and is a major endogenous antioxidant in cells. Its main function is to protect tissues from oxidative stress, which is implicated in the pathogenesis of gastric mucosal injury and ulcer formation. Some animal studies have shown that depletion of glutathione in the gastric mucosa increases susceptibility to damage from non-steroidal anti-inflammatory drugs (NSAIDs), alcohol, and stress, while supplementation or preservation of glutathione levels may confer protective effects. For example, research has demonstrated that glutathione administration in rats reduces the severity of ethanol-induced gastric lesions by scavenging free radicals and supporting mucosal defense mechanisms.

However, direct clinical trials in humans using oral L-glutathione to treat or prevent peptic ulcers are extremely limited or lacking. Most human data focus on the general importance of antioxidants or on glutathione precursors (like N-acetylcysteine) rather than glutathione itself. Furthermore, oral bioavailability of L-glutathione is debated, as it may be broken down in the gut before reaching systemic circulation. While the theoretical rationale and animal evidence are promising, current scientific validation in humans is weak, placing the evidence at a 2 on the scale. Therefore, while some scientific rationale exists, L-glutathione is not a mainstream or well-established therapy for ulcers.

More about L-glutathione
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Other ingredients used for Ulcers

cutch
Akkermansia muciniphila
Alfalfa
Aloe vera
annatto
anthocyanins
apple
apricot
arjun tree
astragalus
bacillus coagulans
bacillus subtilis
bamboo
barberry
barley
berry flavor
beta-glucan
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum
bilberry
black currant
black garlic
bupleurum falcatum
butyrate triglyceride
caterpillar mushroom
cauliflower
chaga mushroom
champignon
chicory
colostrum
curcumin
cuspidatum root
d-alpha tocopherol
diallyl disulfide (DADS)
dong quai root
Melon
epigallocatechin gallate (EGCG)
fennel
flaxseed
gentian root
grape
green banana
green tea
heartwood
hesperetin
Indian gum arabic tree
honeysuckle
knotweed
Japanese sophora
jujube
L-carnosine
L-cysteine
L-glutathione
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus salivarius
Lactococcus lactis
licorice root
luteolin
mango
mangosteen
Marshmallow
Melatonin
Methylmethionine sulfonium chloride (vitamin U)
Mint
N-acetyl-glucosamine
oat
okra
oleanolic acid
olive
pectin
perilla
phospholipids
pine bark
platycodon root
pomegranate
pomelo
pumpkin
quail egg
quercetin
redcurrant
rehmannia glutinosa
resveratrol
rhubarb root
rose hips
sage
slippery elm bark
spirulina
sulforaphane glucosinolate
tocotrienols
tributyrin
vitamin C
Watercress
wheat grass
Whey protein
Mulberry
Zinc
bentonite
sarsaparilla
Yellow root
cardamom
Neem tree
Enicostemma littorale
Pterocarpus marsupium
alpinia galangal
anise
pistacia integerrima gall
holarrhena antidysenterica
Fumaria parviflora
picrorhiza kurroa
Rubia cordifolia
Swertia
bee pollen
blessed thistle
lingzhi
Yarrow
prickly ash
elecampane
broomrape
flowering quince
dogwood
lotus seed
birch
sodium alginate
sheep's sorrel
queen of the meadow
caraway
purslane
Wood betony
biota seed
goji berry
White oak
Alginic acid
Algae
ashitaba
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
arugula
Akebia
Agastache
Autumn elaeagnus
Ardisia
Acacia
Agave
Agrimony
apigenin
Aronia melanocarpa
Antrodia camphorata
Achyranthes
Abrus
Alchornea
American Pawpaw
Amomum
Asarum heterotropoides
Albizia
Alchemilla
asafoetida
aucubin
Anserina
Asam gelugor
astragaloside
arrowroot
anthocyanidins
Andrographis
Alstonia scholaris
Agrimonia pilosa
Acemannan
Algin
Anemarrhena
Abuta
Alstonia macrophylla
Amor seco
Arani
Arisaema
astragalin
buttermilk
bermuda grass
bai ji
Baliospermum
Baphicacanthus cusia
blackthorn
bergenin
betulinic acid
bicarbonate
Blepharis
Brassica
Boswellic Acid
belleric myrobalan
bistort
big quaking grass
baicalein
bael
bloodroot
butternut
Basidiomycota
boldo
black gram
Boswellia
bethroot
banyan
barbasco
bitter principals
banana
baobab
Bifidobacteria
Bupleurum
bacoside
baicalin
Buckwheat
Belamcanda
Bergenia
bignay
bottle gourd
caffeic Acid
cumin
centaury
Centella triterpenes
Casearia esculenta
croton seeds
carqueja
catalpol
chebulic acid
coriander
Clerodendrum phlomidis
carvacrol
cape aloe
Centaurium erythraea
cyanidin
cruciferous
catechu
Centella asiatica
celandine
cinnamic acid
chard
Cinidium
Campylandra fimbriata
colombo
corktree
cubeb
C-phycocyanin
carob
cabbage
cranesbill
Carlina
calamus
chestnut
chebulinic acid
corilagin
Cynodon dactylon
cassava
Chiococca alba
Cynanchum
Casearia sylvestris
carnosic acid
Didymocarpus
dwarf morning glory
date
David\'s milkberry
epicatechin
emblicanin
endive
ellagitannin
emodin
fig
fumitory
flavanones
ficin
fleabane
frankincense
flavones
false calumba
gallic acid
goldthread
geraniol
genipap
garcinol
Glutamine
Gelidiella acerosa
Gac
gentian
Gypenoside
Glycosaponin
galangin
Glycine
garden cress
Gardenia jasminoides
Glycyrrhetinic acid
Gentiana calycosa
Glycyrrhizin
golden shower tree
Gentiana manshurica
Guazuma ulmifolia
Glucosinolates
Hyperoside
hydroxycinnamic acid
Hemidesmus
Houttuynia
honey loquat syrup
huckleberry
hericium mushroom
honeybush
Isoalantolactone
isoliquiritigenin
Indian sarsparilla
isothiocyanates
Jurubeba
Jatoba
Javanese Long Pepper
Java brucea
Kaempferol
Kutkins
Kombucha
kuding tea
Kefiran
Lactobacillus plantarum
Large-leaf gentian
Lactobacillus kefiranofaciens
limonoid
Lactococcus rhamnosus
Lophira lanceolata
limonene
longan
Ligustrum
Lindera
Land Cress
lotus
Leptadenia
Lactobacillus johnsonii
leucoanthocyanidins
Lactobacillus
liverwort
Loranthus
L. lactis
Lysimachia
Molasses
Mesua
Mezoneuron benthamianum
Mung bean
Marjoram
Mucilage
Marine protein
Myricetin
Millet
Matico
Mesquite
Microtea debilis
Mondo grass
mangostene xanthone
Meadowsweet
Marking Nut Tree
Millettia
manzanita
Maytenus ilicifolia
Nardostachys
Natsudaidai
Night jessamine
Oak
orchid
Operculina turpethum
Oxymatrine
Opuntia streptacantha
Osthole
Piper chaba
Pinellia ternata
Pepper Bark Tree
Polydatin
Polypodium
Piper retrofractum
Pentatropis capensis
parasol mushroom
Prickly Pear Cactus
Plumbago zeylanica
Pimpinella
Persimmon
Pedra hume
Prosopis
Qin Jiao
quince
Quebracho
Rubus
Rehmannia
rose
Rhus coriaria
Rhamnus nakaharai
Rosa roxburghii
rhubarb
Spilanthes
Speedwell
Scoparia dulcis
Shikonin
Sangre de Grado
Snakeroot
Scimitar bean
Southernwood
Sesquiterpenic Acid
S-Methylmethionine
Shen Qu
Sarivan
Solanum anguivi
Salvianolic acid
Savory
Semecarpus anacardium
saponins
Simaruba
Stachytarpheta cayennensis
Scopoletin
Silybum
Shilajit
Servicetree
Tannins
Tarragon
Takuna
Taraxasterol
Tragacanth
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Uncaria
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Vidanga
Verbascoside
Withanolides
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Xanthone
Yuzu
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Yellow Nut Sedge
Yellow Dock

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