Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Melatonin, a hormone primarily known for regulating sleep-wake cycles, has been studied for its potential role in supporting and treating gastric and duodenal ulcers. There is a moderate level of scientific evidence suggesting that melatonin may have gastroprotective effects. Research indicates that melatonin is synthesized not only in the pineal gland but also in the gastrointestinal tract, where it appears to play a role in mucosal protection.

Experimental studies in animals have shown that melatonin can reduce the formation of stress-induced gastric ulcers and promote the healing of existing ulcers. The mechanisms proposed include its antioxidant properties, stimulation of mucus and bicarbonate secretion, inhibition of gastric acid secretion, and modulation of inflammatory responses. Melatonin may also enhance microcirculation within the gastric mucosa, further supporting tissue repair.

In humans, a few small clinical trials have explored the use of melatonin in patients with peptic ulcers. Some studies have reported that melatonin supplementation, alone or in combination with standard anti-ulcer medications, may accelerate ulcer healing and reduce symptoms. However, the clinical evidence is still limited by small sample sizes and methodological differences.

Overall, while melatonin is not a standard therapy for ulcers, there is a growing body of preclinical and preliminary clinical research supporting its adjunctive use. Larger, well-controlled human trials are needed to confirm its safety and efficacy in ulcer treatment.

More about melatonin
More about Ulcers

Other ingredients used for Ulcers

Other health conditions supported by melatonin

Products containing melatonin

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Designs For Health Insomnitol™ Capsules
Designs For Health Insomnitol™ Chewables
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Pure Encapsulations Liquid Melatonin
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Thorne Melaton-5
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Pure Encapsulations Melatonin 0.5 mg
Douglas Laboratories Melatonin 1 mg
Douglas Laboratories Melatonin 3 mg
Pure Encapsulations Melatonin 20 mg
Pure Encapsulations Melatonin 20 mg
Pure Encapsulations Melatonin 3 mg
Pure Encapsulations Melatonin 3 mg
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Designs For Health Melatonin SRT™
Metagenics MetaSleep®
Integrative Therapeutics ProThrivers Wellness Sleep