Evidence supporting the use of: Glycyrrhizic acid
For the body system: Urinary System
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Glycyrrhizic acid, a principal component of licorice root (Glycyrrhiza glabra), has a long history of use in traditional herbal medicine, particularly in Asian and Middle Eastern systems. Licorice root has been used for its anti-inflammatory, antimicrobial, and soothing properties, and it is sometimes included in traditional remedies aimed at supporting urinary tract health, especially for its purported ability to soothe mucous membranes and reduce irritation.
However, direct scientific evidence specifically supporting glycyrrhizic acid for urinary system support is limited. Most research on glycyrrhizic acid has focused on its effects on the liver, its anti-viral properties, and its ability to modulate inflammation. A few studies and reviews mention its possible benefits in protecting epithelial tissues and its mild diuretic effect, which may underlie its traditional use in urinary health formulas. Some in vitro studies suggest antibacterial activity against pathogens involved in urinary tract infections, but these findings are preliminary and not well-established in human clinical trials.
In summary, the use of glycyrrhizic acid or licorice root in urinary system support is primarily based on traditional herbal practices rather than robust scientific validation. Its historical use is recognized, but high-quality clinical evidence is lacking, and potential side effects—such as hypertension from prolonged use—should be considered.
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