Cape gooseberry (Physalis peruviana), also known as goldenberry or ground cherry, has a history of use in traditional medicine systems, particularly in South America, Africa, and parts of Asia. In various folk medicinal practices, different parts of the plant—especially the fruit and leaves—have been used for a variety of ailments, including respiratory conditions, fever, and urinary tract infections (UTIs). The traditional use for UTIs is based on the belief that Cape gooseberry possesses diuretic and anti-inflammatory properties, which may help in flushing out bacteria from the urinary tract and reducing associated inflammation.

Scientific research on Cape gooseberry’s efficacy specifically for treating or supporting UTIs is limited. Some in vitro studies have identified antimicrobial and anti-inflammatory compounds in the fruit and leaves, such as withanolides, flavonoids, and phenolic acids. However, there is a lack of direct clinical evidence or robust preclinical studies demonstrating its effectiveness against the specific pathogens responsible for UTIs or its impact on UTI symptoms in humans. Thus, while the traditional use is documented and there is a plausible biochemical rationale based on general antimicrobial activity, the scientific evidence remains weak and largely indirect.

In summary, Cape gooseberry is traditionally used for urinary conditions, but there is only limited scientific support, and more rigorous studies are needed to validate its efficacy and safety for UTIs.