Corn silk (Zea mays stigma) has a long history of use in traditional herbal medicine, particularly in Native American, Chinese, and various folk medicine systems, for the treatment and support of urinary tract conditions, including urinary tract infections (UTIs). Traditionally, corn silk is valued for its purported diuretic properties—meaning it promotes increased urine output—which is believed to help "flush out" the urinary tract and reduce irritation or infection. Historical texts and ethnobotanical records from the 19th and 20th centuries document its use as a soothing remedy for urinary discomfort, cystitis, and other bladder-related issues. Preparations such as teas or extracts have been administered for these purposes.

Scientifically, however, direct evidence supporting the efficacy of corn silk for treating or preventing UTIs is limited. Some laboratory and animal studies suggest corn silk may have mild anti-inflammatory and antioxidant effects, and small diuretic effects have been reported. However, well-designed human clinical trials are lacking, and there is no robust scientific consensus validating its effectiveness specifically for UTIs. Thus, while its use is well-documented in traditional medicine, the strength of evidence supporting its use for UTIs is weak (rated 2 out of 5), and more research is needed to confirm any clinical benefit for this condition.