Evidence supporting the use of: Goldenseal
For the health condition: Urinary Tract Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of use in traditional herbal medicine, particularly among Native American and early North American herbalists. Traditionally, goldenseal was used for a variety of infections and inflammatory conditions, including those affecting the urinary tract. The plant contains several alkaloids, most notably berberine, which has demonstrated antimicrobial activity in laboratory settings. This has led to the widespread belief that goldenseal may help combat urinary tract infections (UTIs). However, while there is a reasonable traditional basis for its use, robust clinical evidence in humans is lacking.

Scientific studies on berberine, the active compound in goldenseal, have shown that it can inhibit the growth of various bacteria in vitro, including some that are commonly implicated in UTIs, such as E. coli. Despite these promising laboratory results, there are few, if any, high-quality clinical trials that evaluate the effectiveness or safety of goldenseal specifically for urinary tract infections in humans. Therefore, the evidence remains largely anecdotal and based on traditional use rather than scientific validation. People considering goldenseal for UTIs should be aware of potential risks and drug interactions, and consult with a healthcare provider before use.

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