Evidence supporting the use of: Lactobacillus casei
For the health condition: Urinary Tract Infections

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus casei is a probiotic bacterium that has been studied for its potential to support urinary tract health, including the prevention and adjunct treatment of urinary tract infections (UTIs). The rationale for its use is primarily based on the ability of certain probiotic strains, including L. casei, to colonize the genitourinary tract and inhibit the growth of uropathogens such as Escherichia coli through competition for adhesion sites and production of antimicrobial substances (bacteriocins, lactic acid). Several small clinical studies and laboratory investigations have shown that oral or intravaginal administration of probiotic strains (including L. casei, though more evidence exists for other species like L. rhamnosus and L. reuteri) can reduce the recurrence of UTIs, especially in women with recurrent infections.

However, the overall quality and quantity of scientific evidence specifically for L. casei is limited. Most research focuses on other Lactobacillus species, and clinical trials using L. casei often involve it as part of a multi-strain preparation, making it difficult to attribute benefits solely to this strain. Systematic reviews and meta-analyses generally conclude that probiotics may offer a modest reduction in UTI recurrence, but more robust randomized controlled trials are needed, especially for L. casei specifically. Therefore, while there is scientific rationale and some preliminary evidence, the strength of evidence is low (rated 2/5), and L. casei cannot be considered a primary or proven treatment for UTIs at this time.

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