Evidence supporting the use of: Saponins
For the health condition: Urinary Tract Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Saponins are naturally occurring compounds found in various plants, including herbs traditionally used in folk medicine. Their use in supporting or treating urinary tract infections (UTIs) is primarily based on traditional practices rather than robust scientific validation. Several plants rich in saponins, such as Tribulus terrestris, Glycyrrhiza glabra (licorice), and Quillaja saponaria, have been used historically in different cultures to support urinary health or as diuretics. The presumed benefits are attributed to saponins' surface-active properties, which may help reduce microbial adhesion to urinary tract surfaces, and their mild anti-inflammatory and immune-modulating effects. However, scientific studies specifically evaluating saponins for the treatment or prevention of UTIs in humans are very limited. Some in vitro and animal studies suggest saponins may possess antimicrobial activity against certain uropathogens, but these findings have not been consistently replicated in clinical trials. The evidence supporting saponins' efficacy for UTIs in human populations is sparse and mostly anecdotal, lacking rigorous randomized controlled trials. In summary, the use of saponins for UTIs is rooted in traditional herbal medicine, with some plausible mechanisms suggested by preliminary laboratory research. Nevertheless, the current scientific evidence does not strongly support their clinical use for this purpose, and more well-designed human studies are needed to establish efficacy and safety.

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