Evidence supporting the use of: Sarsaparilla
For the health condition: Urinary Tract Infections

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Sarsaparilla (Smilax spp.) has a long history of traditional use in herbal medicine, particularly in Central and South America, as well as in Ayurveda and Traditional Chinese Medicine. Historically, it has been used as a “blood purifier” and to support kidney and urinary tract health, including the treatment of urinary tract infections (UTIs). The rationale for its use in UTIs is largely based on its purported diuretic effect—helping to increase urine flow—which, in theory, could help flush bacteria from the urinary tract. Additionally, traditional herbalists have valued sarsaparilla for its supposed anti-inflammatory and detoxifying properties.

However, scientific validation is limited. There are very few clinical studies directly evaluating sarsaparilla’s effectiveness for UTIs. Some in vitro research has shown mild antibacterial or anti-inflammatory activity of certain compounds found in sarsaparilla (such as saponins and flavonoids), but these findings have not been robustly translated into clinical practice or large human trials. Major pharmacological references and systematic reviews do not recognize sarsaparilla as an evidence-based treatment for UTIs. Thus, while its use is supported by tradition, current scientific evidence is weak, meriting a low evidence rating.

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