Evidence supporting the use of: D-mannose
For the health condition: Urination (burning or painful)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

D-mannose is a type of simple sugar that has gained popularity for its use in supporting urinary tract health, especially in individuals experiencing symptoms like burning or painful urination—often linked to urinary tract infections (UTIs). The scientific basis for D-mannose's use comes from its mechanism of action: it inhibits the adhesion of certain bacteria, especially Escherichia coli (E. coli), to the walls of the urinary tract. E. coli is responsible for the majority of UTIs. When D-mannose is consumed, it is excreted in the urine, where it can bind to these bacteria and help flush them out during urination.

Several clinical studies have investigated D-mannose for both the prevention and treatment of recurrent UTIs. For example, a 2014 randomized controlled trial found that women taking D-mannose powder had a significantly lower risk of recurrent UTI compared to those taking placebo, and a similar effect to those using antibiotics. Systematic reviews and meta-analyses suggest D-mannose may be effective in reducing recurrence rates and alleviating symptoms such as burning or painful urination. However, the overall quality and number of studies is moderate, with some limitations in study size and methodology, which is why the evidence rating is not higher.

In summary, D-mannose is scientifically validated to some extent for reducing urinary symptoms related to mild UTIs, though more high-quality research is needed. It is not a substitute for antibiotics in severe cases, but may be considered as a preventative or adjunctive approach for mild or recurrent symptoms.

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