Evidence supporting the use of: Vitamin B9 (calcium methylfolate)
For the body system: Uterus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, also known as folate or calcium methylfolate (the active form), has substantial scientific evidence supporting its role in reproductive health, specifically related to the uterus and pregnancy. Folate is essential for DNA synthesis, cell division, and tissue growth, all of which are critical processes during early pregnancy as the uterus prepares to support a developing embryo. Adequate folate intake before and during early pregnancy is scientifically validated to reduce the risk of neural tube defects (NTDs) in the fetus. Additionally, folate deficiency is associated with increased risk of miscarriage, placental abruption, and other pregnancy complications, reflecting its importance for uterine and placental health.

Most clinical guidelines recommend folate supplementation for women of childbearing age, especially those planning pregnancy. The Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), and numerous obstetric associations underscore the necessity of folate for preventing NTDs and supporting healthy fetal development. Although the direct effect of folate on the uterus itself is less studied than its effects on the embryo, the underlying mechanisms—supporting rapid cell proliferation and reducing homocysteine levels (which may affect uterine blood flow)—are well-established.

In summary, calcium methylfolate is scientifically justified to support uterine health, mainly in the context of pregnancy and preconception care, with strong evidence and broad clinical support.

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