Evidence supporting the use of: Vitamin B9 (folic acid)
For the body system: Uterus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, also known as folic acid, has strong scientific validation for its role in supporting female reproductive health, particularly with reference to the uterus and pregnancy. Folic acid is essential for DNA synthesis and cell division, processes that are critical during periods of rapid growth such as pregnancy. Adequate folic acid intake before and during early pregnancy significantly reduces the risk of neural tube defects (NTDs) in the developing fetus, a benefit well-established through numerous randomized controlled trials and epidemiological studies. Neural tube formation involves the uterus as the environment where embryogenesis occurs, thus linking folic acid’s action to uterine health indirectly.

Additionally, folic acid deficiency has been associated with increased risks of miscarriage, premature birth, and low birth weight. Some research suggests that folic acid may also play a role in reducing the risk of other birth defects and in supporting endometrial health, although the evidence here is less robust. Health organizations such as the CDC and WHO recommend folic acid supplementation for women of childbearing age precisely because of its critical benefit to reproductive outcomes. Therefore, the use of folic acid to support uterine and reproductive health is strongly supported by scientific evidence, especially in the context of preconception and pregnancy.

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