Evidence supporting the use of: Isoflavone (unspecified)
For the body system: Vagina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, particularly those derived from soy, are phytoestrogens—plant-derived compounds with estrogen-like activity. Their use to support vaginal health, especially in postmenopausal women, is supported by a modest but growing body of scientific evidence. After menopause, reduced estrogen levels often result in vaginal atrophy, dryness, and discomfort. Isoflavones may help alleviate these symptoms due to their weak estrogenic effect on estrogen receptors in vaginal tissue. Several randomized controlled trials and systematic reviews have investigated the effect of isoflavone supplementation on vaginal health. Some studies report improvements in vaginal cytology (cell health), pH, and subjective symptoms of dryness and discomfort among postmenopausal women taking isoflavone supplements compared to placebo. However, results are mixed, with some trials showing only marginal benefits or no significant effect. The largest benefits seem to occur in women who are not candidates for conventional estrogen therapy or prefer plant-based alternatives. Overall, while there is scientific rationale and some clinical evidence supporting the use of isoflavones for vaginal health, the quality and consistency of the evidence is moderate, and more rigorous research is needed. Authorities such as the North American Menopause Society acknowledge isoflavones as a possible option for mild symptoms but do not consider them a first-line therapy. The evidence base currently supports a rating of 3 out of 5.

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