Evidence supporting the use of: Lactobacillus (mixed)
For the body system: Vagina

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lactobacillus (mixed strains) have strong scientific support for their use in supporting vaginal health. The vagina is naturally colonized by various species of Lactobacillus, which play a crucial role in maintaining a healthy vaginal microbiome. These bacteria help maintain an acidic vaginal pH (typically below 4.5) by producing lactic acid, hydrogen peroxide, and other antimicrobial substances, thereby inhibiting the growth of pathogenic organisms such as Gardnerella vaginalis and Candida species.

Multiple randomized controlled trials and systematic reviews have demonstrated that oral and intravaginal administration of Lactobacillus strains, especially L. crispatus, L. rhamnosus, and L. reuteri, can help restore the normal vaginal flora after disturbances such as antibiotic use or bacterial vaginosis (BV). Some studies have shown a reduction in recurrence rates of BV and vulvovaginal candidiasis when Lactobacillus probiotics are used as adjunctive therapy. The 2021 Cochrane Review and several meta-analyses support the role of certain Lactobacillus-containing probiotics in improving cure rates and preventing recurrence of BV, though the efficacy may depend on the specific strains and delivery methods used.

In summary, there is robust scientific evidence supporting the use of mixed Lactobacillus strains for maintaining and restoring vaginal health, though further research is needed to optimize strain selection and dosing protocols.

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