Evidence supporting the use of: Soybean
For the body system: Vagina

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Soybean (Glycine max) is used to support vaginal health primarily due to its isoflavone content, particularly genistein and daidzein, which are phytoestrogens—plant-derived compounds with estrogen-like activity. Scientific studies have examined soy isoflavones for their effects on symptoms of vaginal atrophy and dryness, especially in peri- and postmenopausal women. Estrogen decline during menopause contributes to vaginal thinning, dryness, and discomfort. Some randomized controlled trials and meta-analyses suggest that soy isoflavones can modestly improve vaginal epithelial maturation and alleviate vaginal dryness, though results are mixed and not uniformly robust. The mechanism is believed to be the weak estrogenic effect of isoflavones acting on estrogen receptors in vaginal tissues, partially compensating for endogenous estrogen loss. Clinical guidelines sometimes mention soy as a non-hormonal option for managing mild menopausal symptoms, including those affecting the vagina, but usually with the caveat that benefits are modest compared to conventional hormone replacement therapy. Overall, while not as well-validated as pharmaceutical estrogens, there is a moderate body of scientific evidence supporting the use of soybean isoflavones for vaginal health, especially in the context of menopause, justifying a mid-range evidence rating.

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