Evidence supporting the use of: Lactobacillus rhamnosus
For the health condition: Vaginitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Evidence for Lactobacillus rhamnosus in Vaginitis

Lactobacillus rhamnosus is a probiotic bacterium commonly investigated for its role in supporting vaginal health, particularly in the context of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC). The scientific rationale stems from the fact that a healthy vaginal microbiota is typically dominated by Lactobacillus species, which help maintain an acidic environment (low pH) that inhibits the growth of pathogenic microorganisms.

Multiple randomized controlled trials and systematic reviews have explored the use of L. rhamnosus, alone or in combination with other Lactobacillus strains (such as L. reuteri or L. crispatus), for preventing and treating vaginitis. Some studies have shown that oral or intravaginal administration of these probiotics can help restore normal flora, reduce recurrence rates of BV and VVC, and alleviate symptoms, especially when used alongside conventional antifungal or antibiotic therapy. For instance, a 2014 meta-analysis (Plummer et al., PLoS One) concluded that probiotics may increase cure rates and reduce recurrences for BV when compared to placebo, though the effect size and consistency vary.

However, the evidence is still rated as moderate (3/5) due to variability in study quality, probiotic formulations, and dosing regimens. Not all studies have found significant benefits, and optimal strains, doses, and routes of administration remain areas of active research. Nonetheless, L. rhamnosus is scientifically validated as a supportive adjunct, but not a standalone treatment, for certain types of vaginitis.

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