Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanosides, a class of flavonoids found in various berries (such as bilberry and black currant), have been studied for their potential benefits in supporting venous circulation and treating varicose veins. Scientific evidence suggests that anthocyanosides may help improve capillary strength, decrease capillary permeability, and enhance venous tone. Several clinical trials and reviews, mostly conducted in Europe, have evaluated extracts rich in anthocyanosides (such as Vaccinium myrtillus extract) on chronic venous insufficiency, a condition closely related to varicose veins.

The mechanism is believed to involve antioxidant activity, stabilization of collagen in blood vessel walls, and reduction of inflammation, all of which can contribute to improved vascular integrity. A number of randomized controlled trials (RCTs) and meta-analyses have reported modest improvements in symptoms such as leg swelling, heaviness, and discomfort compared to placebo. However, most studies are small, of short duration, and sometimes use varying doses and preparations, making direct comparison and firm conclusions challenging.

Overall, the evidence base is moderate (rated 3/5), with some well-conducted studies supporting benefit but lacking the large-scale, high-quality research needed for unequivocal endorsement. Anthocyanosides are generally considered safe with few reported side effects when used as directed. While not a replacement for medical or surgical interventions in severe cases, anthocyanosides may be a reasonable adjunct for mild-to-moderate venous symptoms.

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