Ginkgo flavonglycosides, derived from the leaves of Ginkgo biloba, have a longstanding history of use in traditional medicine systems, particularly in Asia and Europe, for improving circulatory health. Their use for varicose veins is primarily rooted in traditional application rather than robust scientific validation. The rationale for their use is based on the proposed effects of Ginkgo biloba extracts in improving microcirculation, reducing blood viscosity, and exerting antioxidant effects, which could theoretically help with symptoms related to venous insufficiency, such as those seen in varicose veins.

However, direct scientific evidence supporting the specific efficacy of Ginkgo flavonglycosides for the treatment or prevention of varicose veins is limited. Some small clinical studies and animal research suggest that Ginkgo biloba may have beneficial effects on vascular function and endothelial health, but few have focused specifically on varicose veins. Most modern research on Ginkgo biloba centers on cognitive function, peripheral artery disease, and tinnitus. Reviews and meta-analyses commonly note the lack of high-quality, targeted trials for venous disorders.

In summary, while Ginkgo flavonglycosides are traditionally used in some cultures for vascular conditions and there is a plausible mechanism of action, the scientific evidence supporting their use specifically for varicose veins remains weak and inconclusive.