Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Synopsis of Evidence for Hesperidin Methyl Chalcone in Varicose Veins

Hesperidin methyl chalcone (HMC) is a flavonoid derivative commonly used in combination with other bioflavonoids, such as diosmin, for the treatment of chronic venous insufficiency (CVI), including varicose veins. Scientific validation for its use comes from several clinical trials and meta-analyses, primarily from Europe, where HMC and related flavonoids are frequently prescribed for venous disorders.

HMC appears to exert its effects by improving venous tone, reducing capillary permeability, and enhancing lymphatic drainage. Multiple randomized controlled trials (RCTs) and reviews (e.g., Martinez-Zapata et al., Cochrane Database Syst Rev 2016) indicate that combinations containing HMC can reduce symptoms such as leg swelling, pain, and heaviness associated with varicose veins and CVI.

However, most clinical studies test HMC in combination with other flavonoids, making it difficult to isolate its specific efficacy. Although there is moderate-quality evidence supporting the benefit of flavonoid mixtures (including HMC) for improving subjective symptoms and some objective measures in patients with varicose veins and CVI, the evidence is less robust for monotherapy with HMC alone. Side effects are generally mild and infrequent.

In summary, there is scientific evidence—though not of the highest quality or exclusively focused on HMC monotherapy—that supports the use of HMC (typically in combination) for the symptomatic treatment of varicose veins.

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