Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Leucoanthocyanins, also known as proanthocyanidins or condensed tannins, are polyphenolic compounds found in various plants, including grape seeds, pine bark, and certain berries. Their use in supporting or treating varicose veins is primarily based on their vasoprotective and antioxidant properties. There is a moderate body of scientific evidence suggesting that proanthocyanidins can help improve symptoms associated with chronic venous insufficiency (CVI), a condition related to varicose veins. Clinical studies, particularly with standardized extracts such as grape seed proanthocyanidin extract (GSPE) and French maritime pine bark extract (Pycnogenol), have shown benefits such as reduced leg swelling, reduced sensation of heaviness, and improved capillary resistance in patients with venous disorders.

A 2016 meta-analysis published in Phytotherapy Research found that proanthocyanidins significantly improved symptoms of CVI compared to placebo. The mechanism is thought to involve strengthening of blood vessel walls, reduction of capillary permeability, and anti-inflammatory effects. Most studies involve extracts rich in leucoanthocyanins rather than isolated compounds, and they generally report few side effects. However, while the evidence is promising, it is not universally strong or conclusive, as many studies are small or methodologically limited. Thus, while leucoanthocyanins are scientifically validated for venous disorders including varicose veins, the overall quality of evidence warrants a moderate rating.

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