Evidence supporting the use of: Anthocyanidins
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanidins are a group of flavonoid compounds found abundantly in berries, grapes, and certain vegetables. They are known for their antioxidant properties and their ability to stabilize and protect blood vessels. Scientific research supports the use of anthocyanidins, particularly in the form of standardized extracts like bilberry (Vaccinium myrtillus) or grape seed extract, for supporting vein health. Several clinical studies have investigated their effects on chronic venous insufficiency (CVI), a condition characterized by poor vein function in the legs. These studies have demonstrated that anthocyanidin-rich extracts can improve microcirculation, reduce capillary fragility and permeability, and alleviate symptoms such as leg swelling, heaviness, and pain. The proposed mechanisms include strengthening of the vascular wall, inhibition of platelet aggregation, and reduction of oxidative stress.

While the overall quality of evidence is moderate, with some studies being small or lacking long-term follow-up, systematic reviews and meta-analyses generally support a beneficial effect. The European Medicines Agency has acknowledged the traditional and scientific use of anthocyanidin-containing extracts for relieving symptoms of minor venous circulatory disturbances. Therefore, while more large-scale, high-quality trials are needed, the current scientific evidence justifies the use of anthocyanidins for supporting the veins body system.

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