Centella asiatica, commonly known as gotu kola, has a long history of use in traditional medicine systems, particularly in Ayurveda and Traditional Chinese Medicine, for supporting vascular health. Modern scientific research has provided evidence that supports its use for venous disorders, particularly chronic venous insufficiency (CVI) and varicose veins. The active compounds in Centella asiatica, known as triterpenoids (notably asiaticoside and madecassoside), have been shown in clinical studies to improve microcirculation and strengthen the walls of veins. Several randomized controlled trials have demonstrated that standardized extracts of Centella asiatica can reduce symptoms such as edema, heaviness, and pain in patients with CVI, likely by improving endothelial function and reducing capillary filtration.

For example, a meta-analysis (Cesarone et al., 2001) and several double-blind studies found significant improvements in venous tone, reduction in capillary permeability, and improvements in subjective symptoms when compared to placebo. The European Medicines Agency recognizes Centella asiatica as a traditional herbal medicinal product for the relief of minor venous circulatory disturbances, supporting its use in this context. However, more large-scale, high-quality studies are needed to fully establish its efficacy and safety profile. Overall, there is moderate scientific evidence supporting the use of Centella asiatica for vein health.