Evidence supporting the use of: Escin
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Escin is a natural mixture of triterpene saponins extracted from horse chestnut (Aesculus hippocastanum) seeds. Its primary use in supporting the venous system is scientifically validated, particularly for the treatment of chronic venous insufficiency (CVI), varicose veins, and related conditions such as edema and leg swelling. Multiple randomized controlled trials and meta-analyses have demonstrated that escin can reduce leg pain, swelling, and heaviness associated with CVI. The mechanism of action is believed to involve increasing venous tone, reducing capillary permeability, and exhibiting anti-inflammatory properties.

A 2012 Cochrane review concluded that horse chestnut seed extract (standardized to escin content) is more effective than placebo in reducing leg pain and swelling in people with CVI, with efficacy comparable to compression stockings in some cases. The European Medicines Agency acknowledges escin’s traditional and well-established use for relief of symptoms of CVI. Side effects are generally mild, including gastrointestinal discomfort and dizziness, though rare allergic reactions can occur.

While most studies support short-term use (up to 12 weeks), long-term safety data are limited. Nonetheless, the consistent positive findings across clinical trials provide a substantial scientific basis for escin’s use in supporting the vein body system.

More about Escin
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Products containing Escin

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