Evidence supporting the use of: Flavanones
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavanones are a subclass of flavonoids commonly found in citrus fruits, such as oranges, lemons, and grapefruits. Scientific research has investigated the effects of flavanones, particularly hesperidin and naringin, on vascular health. Several clinical and preclinical studies have shown that flavanones can improve endothelial function, reduce inflammation, and enhance capillary resistance. These effects are thought to be due to their antioxidant properties, ability to inhibit enzymes involved in inflammation (such as cyclooxygenase and lipoxygenase), and modulation of nitric oxide bioavailability, which plays a crucial role in vascular tone and blood flow.

One area with significant evidence is the use of micronized purified flavonoid fraction (MPFF), which is rich in the flavanones diosmin and hesperidin, for the treatment of chronic venous insufficiency (CVI). Multiple randomized controlled trials and meta-analyses have shown that MPFF can reduce symptoms such as leg swelling, heaviness, and pain in patients with venous disorders. As a result, MPFF is approved as a prescription or over-the-counter remedy for venous insufficiency in various countries.

While the precise mechanisms are still being elucidated, the current body of evidence supports the use of flavanones, particularly in standardized formulations, for supporting the veins and vascular system. However, evidence is stronger for specific extracts (e.g., diosmin/hesperidin combinations) than for generic dietary flavanone consumption.

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