Flavonoid glycosides are a group of plant-based compounds commonly found in foods like citrus fruits, buckwheat, and various medicinal herbs (e.g., Crataegus, Ginkgo biloba, horse chestnut). They have been studied for their ability to support the venous system, particularly in the context of chronic venous insufficiency (CVI), varicose veins, and hemorrhoids. The evidence supporting their use comes primarily from clinical trials and meta-analyses, especially for specific flavonoid glycosides such as diosmin, hesperidin, and rutin.

Multiple randomized controlled trials have shown that micronized purified flavonoid fraction (MPFF; mainly diosmin and hesperidin) can reduce symptoms such as leg swelling, pain, heaviness, and improve quality of life in patients with CVI and varicose veins (Cesarone et al., 2007; Kakkos et al., 2016). The proposed mechanisms include strengthening capillary walls, reducing capillary permeability, improving lymphatic drainage, and exerting anti-inflammatory effects.

Systematic reviews and guidelines (e.g., the International Union of Phlebology) support the use of flavonoid glycosides as adjunctive therapy for venous diseases. While more research could further clarify optimal dosing and populations, the current body of evidence provides a solid scientific basis for their use in supporting venous health.