Evidence supporting the use of: Flavonoid (unspecified)
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavonoids are a diverse group of plant compounds found in many fruits, vegetables, and herbs, and are well-studied for their vascular benefits. Scientific evidence supports the use of certain flavonoids, particularly those like diosmin and hesperidin (commonly found in citrus peels), for supporting venous health. Clinical studies have shown that flavonoid mixtures can reduce symptoms of chronic venous insufficiency (CVI), such as leg swelling, heaviness, and discomfort. Flavonoids are believed to work by improving capillary resistance, reducing capillary permeability, and exerting anti-inflammatory effects on the vascular endothelium. These effects help to strengthen blood vessel walls and enhance venous tone, which is particularly relevant in conditions such as varicose veins and hemorrhoids. Systematic reviews and meta-analyses have found moderate to strong evidence for the efficacy of micronized purified flavonoid fraction (MPFF) in reducing CVI symptoms. While the term "flavonoid (unspecified)" is broad, and effects may differ among specific flavonoids, the overall class is recognized in European and international guidelines as an adjunctive treatment for venous disorders. However, more research is needed to clarify the benefits of individual flavonoids and optimal dosing regimens.

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