Evidence supporting the use of: Flavonones (unspecified)
For the body system: Veins

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavanones are a subclass of flavonoids, primarily found in citrus fruits such as oranges, lemons, and grapefruits. The most well-known flavanones include hesperidin, naringin, and eriocitrin. There is scientific evidence suggesting that flavanones may benefit the venous system, particularly through their antioxidant and anti-inflammatory properties. Several clinical studies have examined citrus flavanones, particularly hesperidin (often in combination with diosmin), for their role in managing chronic venous insufficiency (CVI) and related disorders like varicose veins and hemorrhoids.

Research indicates that flavanones can help strengthen capillary walls, reduce vascular permeability, and improve venous tone. For example, micronized purified flavonoid fraction (MPFF), which contains 90% diosmin and 10% hesperidin, is widely used in Europe for the treatment of CVI, and multiple randomized controlled trials have reported improvements in symptoms such as leg swelling, heaviness, and pain. The mechanisms are thought to involve modulation of endothelial function, reduction of oxidative stress, and inhibition of inflammatory mediators.

However, most of the clinical evidence pertains to specific flavanones like hesperidin, especially when combined with diosmin, rather than flavanones as an unspecified group. While promising, the evidence is moderate rather than overwhelming, and more research is needed to confirm benefits for all flavanones across diverse populations. Nevertheless, the current scientific data supports the use of certain flavanones for venous health.

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