Evidence supporting the use of: Glycosaminoglycan
For the body system: Veins

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycosaminoglycans (GAGs), such as heparan sulfate, chondroitin sulfate, and hyaluronic acid, are naturally occurring polysaccharides that play structural and functional roles in connective tissues, including blood vessel walls. There is moderate scientific evidence supporting their role in maintaining vascular health, particularly in the context of chronic venous insufficiency (CVI) and venous disorders. Several clinical studies, mainly with mesoglycan (a mixture of glycosaminoglycans), have shown benefits in improving venous tone, reducing edema, and enhancing microcirculation in patients with CVI, deep vein thrombosis, or post-thrombotic syndrome. For example, randomized controlled trials (RCTs) have demonstrated that oral or injectable GAGs can reduce symptoms such as leg swelling, heaviness, and pain. The likely mechanism involves anti-inflammatory effects, improvement of endothelial function, and modulation of blood coagulation and fibrinolysis. While these results are promising, the overall quality and quantity of studies are limited compared to other standard therapies, and much of the evidence is specific to certain GAG formulations rather than the entire class. Therefore, GAGs are supported by scientific evidence for venous health, but their use is considered adjunctive or complementary rather than first-line treatment.

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Other body systems supported by Glycosaminoglycan

Bladder
Joints
Skeletal System (Bones)
Skin
Structural System
Veins

Products containing Glycosaminoglycan

We currently have no products on Vitabase that contain this ingredient.